Cognitive function maintenance effect of PQQ (pyrroloquinoline quinone)

News field of economic paper (bulletin), "Pebbles and food, tofu development of DHC and for women." There was heading. (2015/6/7 23:30 Nihon Keizai Shimbun electronic edition) This is the news about the product handled by the convenience store of poplar and community store. The tofu of Tabekiri size, is to set the seasoning of olive oil, also contains hyaluronic acid there is a beautiful skin effect as a functional component. It is a private tail study diary today. PQQ is the abbreviation of pyrrolo quinoline quinone, about 10 years ago, the study of a new vitamin is reported, it has been attracting attention. (It should be noted, PQQ itself have been found already in the 1970s, from the action of the PQQ of metabolism, has been shown before about data 10 years that meet the definition of a vitamin, it is history that. Then, with respect to basic research and clinical significance, various discussions have been made. ) Currently, PQQ, in animals and plants, and to act as a growth factor, the metabolism of molecules in transcription factors and in mitochondria such as PPARα, has been found to be related to energy metabolism, such as the promotion of β-oxidation. Also, In the basic research using rats and mice, PQQ (300㎍ / kg ~ 3mg / kg dose) positive impact on growth and reproductive ability of, Such as a protective effect on ischemic state is shown. RIKEN of presentation materials of 2003, it will be seen in the following. For the first time in half a century new vitamin PQQ (pyrroloquinoline quinone) (It will link to the PDF file.) Well, it is a little previous research, Professional journal of nutrition, basic research that showed cognitive function maintenance effect of PQQ, has been reported from a group of Shibaura Institute of Technology. (J Clin Biochem Nutr 2008 Jan; 42:. 29-34.) In this study, Effects on learning and memory ability of PQQ and coenzyme Q10 (CoQ10) has been verified. In particular, Using rat, One of the PQQ or CoQ10 is administered, Evaluation of cognitive function related indicators have been made. First, In the early stages of the Morris water maze test, PQQ administration group, showed excellent learning ability than CoQ10 administration group. As for learning, PQQ + CoQ10 combination group showed improvement of about the same as PQQ administration group, no significant difference was found between the two groups. Then, In the second half of the Morris water maze test, PQQ administration group, CoQ10 administration group, PQQ + CoQ10 combination group, both showed improvement effect of the same degree of learning ability. In addition, In after oxidative stress load of 48 hours, PQQ + CoQ10 combination group, Compared to the control group, It shows a significant improvement effect of storage capacity. (In the PQQ + CoQ10 combination group, significant improvement for the memory impairment caused by oxidative stress has been found to be.) Other, In the study using vitamin E-deficient rats, By the administration of PQQ or CoQ10, but improvement of memory ability in oxidative stress load it has been shown, Storage capacity, and the PQQ administration group than CoQ10 administration group, is that was being maintained. From the above data, For the failure of neuropathy / storage ability of oxidative stress, Independent paths to the antioxidant action of vitamin E, Neuroprotective effect of PQQ, cognitive function (memory function) are suggested protective effect. In the future, it is the field of verification of clinical significance is expected. DHC has commercialized the PQQ-containing supplements. PQQ + Q10 Japan's first, new ingredients! To clean and dull was youthfulness